WebDec 7, 2024 · Gaining biological insights into molecular responses to treatments or diseases from omics data can be accomplished by gene set or pathway enrichment methods. A plethora of different tools and algorithms have been developed so far. Among those, the gene set enrichment analysis (GSEA) proved to control both type I and II errors well. In … WebMar 25, 2024 · Inflammatory bowel disease (IBD) has become a global public health challenge. Our previous study showed that barley leaf (BL) significantly reduces Citrobacter-rodentium (CR)-induced colitis, but its mechanism remains elusive. Thus, in this study, we used non-targeted metabolomics techniques to search for potentially effective …
Chapter 8 Enrichment Analysis Data Analysis in …
WebNov 4, 2024 · Background: Pathway enrichment extensively used in the analysis of Omics data for gaining biological insights into the functional roles of pre-defined subsets of genes, proteins and metabolites. A large number of methods have been proposed in the literature for this task. The vast majority of these methods use as input expression levels of the … WebMar 9, 2024 · Enrichment analysis demonstrated that the upregulated KEGG pathways were significantly (p-value < 0.05) enriched in sphingolipid metabolism, ... While the untargeted metabolomics analysis of lung tissue showed that most glycerophospholipids were decreased in HDM-sensitized mice, the targeted analysis of oxylipins in the same … opus international consultants limited nz
MetaboAnalyst
WebNational Center for Biotechnology Information WebNov 4, 2024 · The two gene expression data sets studied contain at least 100 samples per condition/group, which enable us to include more genes and pathways of potential relevance in the enrichment analysis. The metabolomic data set provides a different perspective as enrichment analysis of metabolomics data presents additional challenges due to the … WebMay 29, 2024 · The number of clusters was set to 10. Enrichment analysis of each of the 10 clusters was performed using the target-list mode with default settings. Enrichment analyses used in Figs 2C and 3A and D were performed using the ranking mode, with 1-tailed Welch 2-sample t-test P-values as local statistics. opus it prosoft